To allow researchers to explore the data in the Clinical Research Data Warehouse (CRDW) prior to making a data request, the CRI operates i2b2, an NIH-funded open-source project created by a National Center for Biomedical Computing based at Partners HealthCare System.
The CRI’s i2b2 web interface is populated with data from the CRDW. Users can explore this data with an intuitive drag-and-drop method and create queries with multiple and/or logic, using search terms based on standard terminologies. The system returns aggregate counts, allowing researchers to determine the number of patients in the CRDW meeting their criteria. These results can inform data requests for de-identified or IRB-approved identified data, as well as helping researchers to formulate hypotheses and identify potential cohorts for research studies and clinical trials.
Q: What are the uses of i2b2?
A: i2b2 can assist researchers in creating new research hypotheses, identifying potential cohorts for clinical trials, and reducing the time spent on study feasibility and subject recruitment. It is also a way for potential CRDW users to become familiar with the data elements we have available.
Q: What credentials do I need to access i2b2?
A: You can access the i2b2 system here with your BSD or UCHAD login credentials. If you do not have a BSD or UCHAD account, you may request one by visiting the BSD Account Request page or contacting the IT Service Desk at 773-702-3456.
You must be on a secure University network to access i2b2. If you’re working off campus, please log into the University’s VPN.
Q: How do I use i2b2 to perform a query?
A: Detailed instructions for using i2b2 are available in our i2b2 User Guide.
Q: Can I export de-identified data from i2b2?
A: The i2b2 interface does not currently support direct exporting of de-identified data. If your cohort discovery results are promising and you would like a full data extract, please follow the process for placing a CRDW data request. However, stay tuned: in 2015 the CRI will launch the SEECohorts data portal, which will allow users to study de-identified data without submitting a data request.
Q: How can I get technical help with i2b2?