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CRI bioinformatics resources highlighted by researchers working to treat zoonotic diseases

By News

A team of University of Chicago scientists is working to find ways to repurpose generic and over-the-counter drugs to treat zoonotic diseases, potentially making treatment for these infections more affordable and accessible worldwide. The CRI Bioinformatics Core’s resources and expertise allowed them to run fast, efficient analyses of the drugs’ effectiveness. Read about their work at the Institute for Translational Medicine.

Bioinformatics Core now offering proteomics analysis

By News
The CRI Bioinformatics Core has expanded its bioinformatics analysis services to include support for proteomics data. The new proteomics analysis pipeline includes raw MS data processing, deisotoping, data conversion, spectral filtering, spectral library creation, extracted ion chromatogram generation (MASIC), peptide and protein identification (X!Tandem, MaxQuant, Mascot, MSGF+), quantification (MaxQuant, Scaffold), targeted assay generation (Skyline), and dataset alignment and feature generation (MultiAlign). Additional proteomics services include profiling of post-translational modifications (phosphorylation, glycosylation, etc.), statistical analysis for labeled and label-free proteomics, and pathway enrichment analysis (Ingenuity Pathway Analysis).

CRI to contribute to New March of Dimes Prematurity Research Center

By News

This month, the March of Dimes Foundation announced a collaboration with the University of Chicago, Northwestern University Feinberg School of Medicine, and Duke Medicine to create a new March of Dimes Prematurity Research Center focused on determining the currently unknown factors causing premature birth.

Under the leadership of PI and Program Director Carole Ober, PhD, the University of Chicago Medicine will have the lead role in this project, to which March of Dimes will contribute $10 million over the next five years. The Center for Research Informatics will contribute bioinformatics and computing resources to this important research.

Read more about the center and the CRI’s contributions here.

CRI’s bioinformatics resources in anesthesiology study

By News

Our bioinformatics analysis resources were highlighted as essential to research by the scientists behind a study that recently appeared in the journal Anesthesiology. The CRI’s large-scale computational resources were a key part of their research, which included analyzing a massive set of medical data. Learn more: ITM Investigators Find Higher Rates of Corneal Abrasion in Robotic Hysterectomies than Open Procedures.