In an interview with Technology Networks, CRI Director Sam Volchenboum offers insights into the future of using big data to fight pediatric cancer and other diseases. In particular, he highlights the need for standardized data models, which will allow researchers to harness the true power of big data by making it easier for data from disparate sources to be harmonized and combined. In addition, advances in genomic research will be made possible when genomic data is linked with more and richer sources of clinical data. The CRI is at work on both of these issues with our initiative in pediatric cancer research data commons.