WELCOME TO THE CRI

AT THE UNIVERSITY OF CHICAGO

FREE CLASSES FOR THE UCHICAGO COMMUNITY

Our new Seminar Series kicks off with Introduction to REDCap on September 1

IN THE NEWS

From the Cancer Moonshot Initiative to sequencing the genomes of prehistoric Himalayan dwellers, the CRI is helping research reach new heights.

10 YEARS OF CLINICAL DATA

Labs, diagnoses, demographics, and more are available for your research in the CRDW.

1
1

GET STARTED NOW

ACQUIRE DATA

Explore clinical data available for research and make a data request.

Clinical Research Data Warehouse
Cohort Discovery

ANALYZE DATA

We offer high-performance computing and advanced bioinformatics analysis for the most complex datasets.

Bioinformatics Core
Computing Resources
CRI Galaxy

STORE DATA

Our storage is secure, standards-compliant, and backed up daily.

CRI Data Storage

MANAGE DATA

Manage studies, surveys, and databases for research.

REDCap

FIND A CUSTOM SOLUTION

Learn more about the CRI’s tailor-made research solutions.

Custom Applications

portfolio image - gain

GAIN Consortium

Genomic Assessment Improves Novel Therapy

portfolio image - gdc

NCI Genomic Data Commons

portfolio image - 1001 genomes

1001 Genomes

portfolio image - simpl

SIMPL

Molecular Pathology Sample Tracking System

Like what you see? We’re just getting started.   RESEARCH. POWERED BY THE CRI.

NEWS

“We are converging on a time when the whole world could become a big clinical trial”

By | News | No Comments

With a recent lawsuit drawing attention to inaccuracies in heart rate data gathered by Fitbits, do wearable health tracking devices have a place in clinical research? CRI Director Sam Volchenboum and Daphne Kis, writing in TechCrunch, look at both sides of the issue and advocate for a path forward that prioritizes both accuracy and usability.

Wearables and other forms of real-time tracking can transform large-scale studies of disease, giving researchers data that is more extensive and more accurate than what patients are able to remember weeks or months later. For example, this UChicago study of IBD patients uses Fitbits to track physical activity, allowing reseachers to find patterns and identify potential symptom triggers. But as Volchenboum and Kis note, “If we want better devices, we must do a better job of telling manufacturers what kinds of measurements and outputs we need. … Standards and data provenance aren’t sexy, but they are absolutely essential to any compelling future vision of clinical research.”

Science Life explores significance of CRI-enabled zebrafish research

By | News | No Comments

A story today in Science Life highlights the research on zebrafish antigen processing genes, conducted in part by the CRI Bioinformatics Core (read about our contribution here), that was recently published in the Proceedings of the National Academy of Sciences. Read the article to hear from the study’s lead author Sean McConnell, PhD, of the Department of Pediatrics about why these new discoveries are so exciting and how research on zebrafish may translate to advances in our understanding of the human immune system.

CRI Bioinformatics Core research published in PNAS

By | News | No Comments

A new publication in the Proceedings of the National Academy of Sciences highlights findings about novel antigen processing and presentation genes in zebrafish. This newly identified genetic diversity, discovered by de novo assembly, represents the most extensive diversity yet seen in the antigen processing genes of any species and fills in previously unrecognized knowledge gaps about the evolution of vertebrate adaptive immunity.

This research was enabled in part by our Bioinformatics Core. CRI Director of Bioinformatics Jorge Andrade, PhD, and Bioinformatician Kyle Hernandez, PhD, are co-authors on the paper. They produced the de novo assembly of the genome of a clonal line of zebrafish, using the CRI’s computing infrastructure for this complex data- and memory-intensive task. They then used many tools to determine which de novo scaffolds aligned near the chromosomal region being studied and aggregated these scaffolds to orient and order them across the region.

Read the full paper here, and see more publications enabled by the CRI here.

EVENTS

CRI Seminar Series: Introduction to REDCap

September 1 @ 2:00 pm - 3:00 pm

We’re kicking off our new seminar series with a free introduction to REDCap, a self-managed, secure, web-based solution designed to support data collection strategies for research studies.

BY THE NUMBERS

CRDW Data Requests Fulfilled

Projects Supported in REDCap

Bioinformatics Projects Completed

Total CRI Training Attendance